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MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors.

Current biology : CB | 2014

Dietary restriction (DR) has been shown to prolong longevity across diverse taxa, yet the mechanistic relationship between DR and longevity remains unclear. MicroRNAs (miRNAs) control aging-related functions such as metabolism and lifespan through regulation of genes in insulin signaling, mitochondrial respiration, and protein homeostasis.

Pubmed ID: 25242029 RIS Download

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: F32 AG030851
  • Agency: NIA NIH HHS, United States
    Id: R01 AG033921
  • Agency: NIA NIH HHS, United States
    Id: 1F32AG030851

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miRBase (tool)

RRID:SCR_003152

Central online repository for microRNA nomenclature, sequence data, annotation and target prediction.Collection of published miRNA sequences and annotation.

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