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Tau reduction prevents disease in a mouse model of Dravet syndrome.

Annals of neurology | 2014

Reducing levels of the microtubule-associated protein tau has shown promise as a potential treatment strategy for diseases with secondary epileptic features such as Alzheimer disease. We wanted to determine whether tau reduction may also be of benefit in intractable genetic epilepsies.

Pubmed ID: 25042160 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

None found

Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: NS066930
  • Agency: NINDS NIH HHS, United States
    Id: K08 NS066930
  • Agency: NINDS NIH HHS, United States
    Id: NS041787
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS041787
  • Agency: NINDS NIH HHS, United States
    Id: NS065780
  • Agency: NCRR NIH HHS, United States
    Id: C06 RR018928
  • Agency: NCRR NIH HHS, United States
    Id: RR18928
  • Agency: NINDS NIH HHS, United States
    Id: P30 NS065780

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This is a list of tools and resources that we have found mentioned in this publication.


WinLTP (tool)

RRID:SCR_008590

WinLTP is a stimulation, data acquisition and on-line analysis electrophysiological software for studying Long-Term Potentiation (LTP), Long-term Depression (LTD), and related phenomena. WinLTP is multitasking and simultaneously runs 1) LTP stimulus/acquisition/analyzing sweeps with protocol scripting, and 2) continuous acquisition saving Axon Binary Files (abf). WinLTP runs on Windows PCI bus computers and uses National Instruments PCI M-Series boards and Axon Instruments'' Digidata 1320A and 1322A data acquisition boards. Other software that can use the M-Series boards includes Axograph Scientific''s AxoGraph X, WaveMetrics'' IGOR, National Instruments'' LabView, John Dempster''s Strathclyde Electrophysiology Suite (WinWCP and WinEDR), Silver lab''s Nclamp, and QUB data acquisition.

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pClamp (tool)

RRID:SCR_011323

Software suite for electrophysiology data acquisition and analysis by Molecular Devices. Used for the control and recording of voltage clamp, current clamp, and patch clamp experiments. The software suite consists of Clampex 11 Software for data acquisition, AxoScope 11 Software for background recording, Clampfit 11 Software for data analysis, and optional Clampfit Advanced Analysis Module for sophisticated and streamlined analysis.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C3HeB/FeJ (tool)

RRID:IMSR_JAX:000658

Mus musculus with name C3HeB/FeJ from IMSR.

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