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Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma.

Molecular cancer | 2014

The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro.

Pubmed ID: 24735930 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P01 CA168585

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ImageQuant (tool)

RRID:SCR_014246

Software for automatic general image analysis. It provides fully automatic analysis of 1-D gels including lane creation, background subtraction, band detection, molecular weight calibration, quantity calibration, and normalization. Editing tools are provided for cropping, rotating, and filtering images.

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