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Prostate is a male sex-accessory organ. The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for bone morphogenetic protein (Bmp) signaling. This study shows that Bmp signaling prominently increases during prostatic differentiation in the luminal epithelia, which is monitored by the expression of phosphorylated Smad1/5/8. To elucidate the mechanism of epithelial differentiation and the function of Bmp signaling during prostatic development, conditional male mutant mouse analysis for the epithelial-specific Bmp receptor 1a (Bmpr1a) was performed. We demonstrate that Bmp signaling is indispensable for luminal cell maturation, which regulates basal cell proliferation. Expression of the prostatic epithelial regulatory gene Nkx3.1 was significantly reduced in the Bmpr1a mutants. These results indicate that Bmp signaling is a key factor for prostatic epithelial differentiation, possibly by controlling the prostatic regulatory gene Nkx3.1.
Pubmed ID: 24731097 RIS Download
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Database of nucleotide sequences from several sources, including GenBank, RefSeq, TPA and PDB. Genome, gene and transcript sequence data provide the foundation for biomedical research and discovery.
View all literature mentionsPipMaker computes alignments of similar regions in two DNA sequences. Moreover, MultiPipMaker can be requested to compute a true multiple alignment of the input sequences and return a nucleotide-level view of the results.
View all literature mentionsAntibody and density gradient media supplier.
View all literature mentionslaboratory mouse with name C57BL/6JJcl from MGI.
View all literature mentionsThis unknown targets Rabbit Dog IgG (H&L) secondary antibody (Peroxidase)
View all literature mentionsThis polyclonal targets BMPR1A
View all literature mentionsThis polyclonal targets Human KIT (C-term)
View all literature mentionsThis polyclonal targets Cytokeratin 19
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets All simple-type epithelia and neoplasms derived therefrom. Stains all adenocarcinomas tested and undifferentiated carcinomas. (Human, monodelphis, mouse, rat, tupaia (not with bovine, pig))
View all literature mentionsThis polyclonal targets ND
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Phospho-EGF Receptor (Tyr1148)
View all literature mentionsThis polyclonal targets Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428)
View all literature mentionsThis polyclonal targets Nkx-3.1 (T-19)
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