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Predictors and moderators of outcomes of HIV/STD sex risk reduction interventions in substance abuse treatment programs: a pooled analysis of two randomized controlled trials.

BACKGROUND: The objective of the current study was to examine predictors and moderators of response to two HIV sexual risk interventions of different content and duration for individuals in substance abuse treatment programs. METHODS: Participants were recruited from community drug treatment programs participating in the National Institute on Drug Abuse Clinical Trials Network (CTN). Data were pooled from two parallel randomized controlled CTN studies (one with men and one with women) each examining the impact of a multi-session motivational and skills training program, in comparison to a single-session HIV education intervention, on the degree of reduction in unprotected sex from baseline to 3- and 6- month follow-ups. The findings were analyzed using a zero-inflated negative binomial (ZINB) model. RESULTS: Severity of drug use (p < .01), gender (p < .001), and age (p < .001) were significant main effect predictors of number of unprotected sexual occasions (USOs) at follow-up in the non-zero portion of the ZINB model (men, younger participants, and those with greater severity of drug/alcohol abuse have more USOs). Monogamous relationship status (p < .001) and race/ethnicity (p < .001) were significant predictors of having at least one USO vs. none (monogamous individuals and African Americans were more likely to have at least one USO). Significant moderators of intervention effectiveness included recent sex under the influence of drugs/alcohol (p < .01 in non-zero portion of model), duration of abuse of primary drug (p < .05 in non-zero portion of model), and Hispanic ethnicity (p < .01 in the zero portion, p < .05 in the non-zero portion of model). CONCLUSION: These predictor and moderator findings point to ways in which patients may be selected for the different HIV sexual risk reduction interventions and suggest potential avenues for further development of the interventions for increasing their effectiveness within certain subgroups.

Pubmed ID: 24433412

Authors

  • Crits-Christoph P
  • Gallop R
  • Sadicario JS
  • Markell HM
  • Calsyn DA
  • Tang W
  • He H
  • Tu X
  • Woody G

Journal

Substance abuse treatment, prevention, and policy

Publication Data

February 20, 2014

Associated Grants

  • Agency: NIDA NIH HHS, Id: R33 DA027521
  • Agency: NIDA NIH HHS, Id: U10 DA013714
  • Agency: NIDA NIH HHS, Id: U10 DA013727
  • Agency: NIDA NIH HHS, Id: U10 DA13035
  • Agency: NIDA NIH HHS, Id: U10 DA13038
  • Agency: NIDA NIH HHS, Id: U10 DA13043
  • Agency: NIDA NIH HHS, Id: U10 DA13045
  • Agency: NIDA NIH HHS, Id: U10 DA13711
  • Agency: NIDA NIH HHS, Id: U10 DA13714
  • Agency: NIDA NIH HHS, Id: U10 DA13727
  • Agency: NIDA NIH HHS, Id: U10 DA13732
  • Agency: NIDA NIH HHS, Id: U10 DA15815
  • Agency: NIDA NIH HHS, Id: U10 DA15833

Mesh Terms

  • Adult
  • Age Factors
  • Drug Users
  • Ethnic Groups
  • Female
  • HIV Infections
  • Humans
  • Male
  • Motivation
  • Patient Education as Topic
  • Psychotherapy, Group
  • Risk Factors
  • Risk Reduction Behavior
  • Sex Factors
  • Sexually Transmitted Diseases
  • Substance Abuse Treatment Centers
  • Substance-Related Disorders
  • Treatment Outcome
  • Unsafe Sex
  • Young Adult