To identify the mutation responsible for an abnormal electroretinogram (ERG) in a transgenic mouse line (tg21) overexpressing erythropoietin (Epo). The tg21 line was generated on a mixed (C3H; C57BL/6) background and lacked the b-wave component of the ERG. This no-b-wave (nob) ERG is seen in other mouse models with depolarizing bipolar cell (DBC) dysfunction and in patients with the complete form of congenital stationary night blindness (cCSNB). We determined the basis for the nob ERG phenotype and screened C3H mice for the mutation to evaluate whether this finding is important for the vision research community.
Pubmed ID: 24415894 RIS Download
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Software designed to quickly find sequences of 95% and greater similarity of length 25 bases or more.
View all literature mentionslaboratory mouse with name C3H/HeH from MGI.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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