Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience | 2013

Glial fibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammalian CNS. Dominant gain of function mutations in GFAP lead to the fatal neurodegenerative disorder, Alexander disease (AxD), which is characterized by cytoplasmic protein aggregates known as Rosenthal fibers along with variable degrees of leukodystrophy and intellectual disability. The mechanisms by which mutant GFAP leads to these pleiotropic effects are unknown. In addition to astrocytes, GFAP is also expressed in other cell types, particularly neural stem cells that form the reservoir supporting adult neurogenesis in the hippocampal dentate gyrus and subventricular zone of the lateral ventricles. Here, we show that mouse models of AxD exhibit significant pathology in GFAP-positive radial glia-like cells in the dentate gyrus, and suffer from deficits in adult neurogenesis. In addition, they display impairments in contextual learning and spatial memory. This is the first demonstration of cognitive phenotypes in a model of primary astrocyte disease.

Pubmed ID: 24259590 RIS Download

Research resources used in this publication

None found

Additional research tools detected in this publication

None found

Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: P30 HD003352
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS060120
  • Agency: NICHD NIH HHS, United States
    Id: P30-HD03352
  • Agency: NINDS NIH HHS, United States
    Id: P01-NS42803
  • Agency: NINDS NIH HHS, United States
    Id: P01 NS042803
  • Agency: NINDS NIH HHS, United States
    Id: R01-NS060120

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Anti-GFAP Antibody (antibody)

RRID:AB_10672298

This monoclonal targets GFAP

View all literature mentions

Anti-GFAP Antibody (antibody)

RRID:AB_10672299

This monoclonal targets GFAP

View all literature mentions