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Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain.

Nature neuroscience | Oct 26, 2013

To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.

Pubmed ID: 23995069 RIS Download

Mesh terms: Age Factors | Animals | Brain | Cell Differentiation | Cell Transplantation | Mice | Mice, Inbred C57BL | Mice, Transgenic | Neurogenesis | Oligodendroglia

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