Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

GluN2B in corticostriatal circuits governs choice learning and choice shifting.

Nature neuroscience | Aug 26, 2013

A choice that reliably produces a preferred outcome can be automated to liberate cognitive resources for other tasks. Should an outcome become less desirable, behavior must adapt in parallel or it becomes perseverative. Corticostriatal systems are known to mediate choice learning and flexibility, but the molecular mechanisms of these processes are not well understood. We integrated mouse behavioral, immunocytochemical, in vivo electrophysiological, genetic and pharmacological approaches to study choice. We found that the dorsal striatum (DS) was increasingly activated with choice learning, whereas reversal of learned choice engaged prefrontal regions. In vivo, DS neurons showed activity associated with reward anticipation and receipt that emerged with learning and relearning. Corticostriatal or striatal deletion of Grin2b (encoding the NMDA-type glutamate receptor subunit GluN2B) or DS-restricted GluN2B antagonism impaired choice learning, whereas cortical Grin2b deletion or OFC GluN2B antagonism impaired shifting. Our convergent data demonstrate how corticostriatal GluN2B circuits govern the ability to learn and shift choice behavior.

Pubmed ID: 23831965 RIS Download

Mesh terms: Adaptation, Psychological | Animals | Anticipation, Psychological | Choice Behavior | Conditioning, Operant | Corpus Striatum | Decision Making | Discrimination Learning | Excitatory Amino Acid Antagonists | Gene Deletion | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Nerve Net | Nerve Tissue Proteins | Neuronal Plasticity | Patch-Clamp Techniques | Pattern Recognition, Visual | Phenols | Piperidines | Prefrontal Cortex | Receptors, N-Methyl-D-Aspartate | Reward

Research resources used in this publication

None found

Research tools detected in this publication

Data used in this publication

None found

Associated grants

  • Agency: Medical Research Council, Id: MRC_G0001354
  • Agency: Wellcome Trust, Id: WT089703
  • Agency: Intramural NIH HHS, Id: ZIA AA000411-09
  • Agency: Wellcome Trust, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Jackson Laboratory

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

tool

View all literature mentions