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Advances in diffusion MRI acquisition and processing in the Human Connectome Project.

NeuroImage | Oct 15, 2013

The Human Connectome Project (HCP) is a collaborative 5-year effort to map human brain connections and their variability in healthy adults. A consortium of HCP investigators will study a population of 1200 healthy adults using multiple imaging modalities, along with extensive behavioral and genetic data. In this overview, we focus on diffusion MRI (dMRI) and the structural connectivity aspect of the project. We present recent advances in acquisition and processing that allow us to obtain very high-quality in-vivo MRI data, whilst enabling scanning of a very large number of subjects. These advances result from 2 years of intensive efforts in optimising many aspects of data acquisition and processing during the piloting phase of the project. The data quality and methods described here are representative of the datasets and processing pipelines that will be made freely available to the community at quarterly intervals, beginning in 2013.

Pubmed ID: 23702418 RIS Download

Mesh terms: Brain | Connectome | Diffusion Tensor Imaging | Humans | Models, Anatomic | Models, Neurological | Nerve Net

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Associated grants

  • Agency: NIBIB NIH HHS, Id: P41 EB015894
  • Agency: NIMH NIH HHS, Id: F30 MH097312
  • Agency: NIMH NIH HHS, Id: 1U54MH091657-01
  • Agency: Wellcome Trust, Id: 098369
  • Agency: NIMH NIH HHS, Id: R01 MH060974
  • Agency: NINDS NIH HHS, Id: P30 NS076408
  • Agency: NCRR NIH HHS, Id: S10 RR022984
  • Agency: NCRR NIH HHS, Id: 1S10RR022984-01A1
  • Agency: NIMH NIH HHS, Id: R01 MH60974
  • Agency: NIMH NIH HHS, Id: U54 MH091657
  • Agency: NINDS NIH HHS, Id: P30 NS057091
  • Agency: Wellcome Trust, Id: 090955
  • Agency: Medical Research Council, Id: G0800578

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WU-Minn Consortium: Human Connectome Project

Consortium to comprehensively map long-distance brain connections and their variability. It is acquiring data and developing analysis pipelines for several modalities of neuroimaging data plus behavioral and genetic data from healthy adults.


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