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Advances in diffusion MRI acquisition and processing in the Human Connectome Project.

The Human Connectome Project (HCP) is a collaborative 5-year effort to map human brain connections and their variability in healthy adults. A consortium of HCP investigators will study a population of 1200 healthy adults using multiple imaging modalities, along with extensive behavioral and genetic data. In this overview, we focus on diffusion MRI (dMRI) and the structural connectivity aspect of the project. We present recent advances in acquisition and processing that allow us to obtain very high-quality in-vivo MRI data, whilst enabling scanning of a very large number of subjects. These advances result from 2 years of intensive efforts in optimising many aspects of data acquisition and processing during the piloting phase of the project. The data quality and methods described here are representative of the datasets and processing pipelines that will be made freely available to the community at quarterly intervals, beginning in 2013.

Pubmed ID: 23702418

Authors

  • Sotiropoulos SN
  • Jbabdi S
  • Xu J
  • Andersson JL
  • Moeller S
  • Auerbach EJ
  • Glasser MF
  • Hernandez M
  • Sapiro G
  • Jenkinson M
  • Feinberg DA
  • Yacoub E
  • Lenglet C
  • Van Essen DC
  • Ugurbil K
  • Behrens TE
  • WU-Minn HCP Consortium

Journal

NeuroImage

Publication Data

October 15, 2013

Associated Grants

  • Agency: Wellcome Trust, Id: 090955
  • Agency: Wellcome Trust, Id: 098369
  • Agency: NCRR NIH HHS, Id: 1S10RR022984-01A1
  • Agency: NIMH NIH HHS, Id: 1U54MH091657-01
  • Agency: NIMH NIH HHS, Id: F30 MH097312
  • Agency: NINDS NIH HHS, Id: P30 NS057091
  • Agency: NINDS NIH HHS, Id: P30 NS076408
  • Agency: NIBIB NIH HHS, Id: P41 EB015894
  • Agency: NIMH NIH HHS, Id: R01 MH60974
  • Agency: NIMH NIH HHS, Id: U54 MH091657

Mesh Terms

  • Brain
  • Connectome
  • Diffusion Tensor Imaging
  • Humans
  • Models, Anatomic
  • Models, Neurological
  • Nerve Net