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Spatiotemporal linear mixed effects modeling for the mass-univariate analysis of longitudinal neuroimage data.

NeuroImage | Nov 1, 2013

http://www.ncbi.nlm.nih.gov/pubmed/23702413

We present an extension of the Linear Mixed Effects (LME) modeling approach to be applied to the mass-univariate analysis of longitudinal neuroimaging (LNI) data. The proposed method, called spatiotemporal LME or ST-LME, builds on the flexible LME framework and exploits the spatial structure in image data. We instantiated ST-LME for the analysis of cortical surface measurements (e.g. thickness) computed by FreeSurfer, a widely-used brain Magnetic Resonance Image (MRI) analysis software package. We validate the proposed ST-LME method and provide a quantitative and objective empirical comparison with two popular alternative methods, using two brain MRI datasets obtained from the Alzheimer's disease neuroimaging initiative (ADNI) and Open Access Series of Imaging Studies (OASIS). Our experiments revealed that ST-LME offers a dramatic gain in statistical power and repeatability of findings, while providing good control of the false positive rate.

Pubmed ID: 23702413 RIS Download

Mesh terms: Brain | Humans | Image Interpretation, Computer-Assisted | Linear Models | Magnetic Resonance Imaging | Models, Neurological | Software

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Associated grants

  • Agency: NIBIB NIH HHS, Id: 1K25EB013649-01
  • Agency: NINDS NIH HHS, Id: 1R01NS070963
  • Agency: NINDS NIH HHS, Id: 1R21NS072652-01
  • Agency: NCRR NIH HHS, Id: 1S10RR019307
  • Agency: NCRR NIH HHS, Id: 1S10RR023043
  • Agency: NCRR NIH HHS, Id: 1S10RR023401
  • Agency: NINDS NIH HHS, Id: 2R01NS042861-06A1
  • Agency: NINDS NIH HHS, Id: 5P01NS058793-03
  • Agency: NIMH NIH HHS, Id: 5U01-MH093765
  • Agency: NIA NIH HHS, Id: AG022381
  • Agency: NIBIB NIH HHS, Id: K25 EB013649
  • Agency: NIA NIH HHS, Id: P01 AG003991
  • Agency: NCRR NIH HHS, Id: P41-RR14075
  • Agency: NIA NIH HHS, Id: R01 AG008122
  • Agency: NIA NIH HHS, Id: R01 AG008122
  • Agency: NIA NIH HHS, Id: R01 AG016495
  • Agency: NIA NIH HHS, Id: R01 AG016495
  • Agency: NINDS NIH HHS, Id: R01 NS052585-01
  • Agency: NICHD NIH HHS, Id: R01-HD071664
  • Agency: NIBIB NIH HHS, Id: R01EB006758
  • Agency: NCCIH NIH HHS, Id: RC1 AT005728-01
  • Agency: NIA NIH HHS, Id: U01 AG024904

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