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Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

PloS one | 2013

Heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form a complex and play key roles in homologous recombination (HR), DNA double strand break (DSB) repair and cell cycle regulation following DNA damage.

Pubmed ID: 23585894 RIS Download

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MC_U105185858
  • Agency: NCI NIH HHS, United States
    Id: P30 CA072720
  • Agency: NCI NIH HHS, United States
    Id: R01 CA138804
  • Agency: NCI NIH HHS, United States
    Id: R01CA138804

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HeLa S3 (tool)

RRID:CVCL_0058

Cell line HeLa S3 is a Cancer cell line with a species of origin Homo sapiens (Human)

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