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Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development.

Epigenetics & chromatin | 2013

The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report the production and phenotypic analysis of mice and cells with targeted disruption of the H3.3-encoding gene, H3f3b.

Pubmed ID: 23570311 RIS Download

Research resources used in this publication

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P30 CA093373
  • Agency: NIGMS NIH HHS, United States
    Id: R01 GM100782

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ImageJ (tool)

RRID:SCR_003070

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Bioconductor (tool)

RRID:SCR_006442

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Illumina (tool)

RRID:SCR_010233

American company incorporated that develops, manufactures and markets integrated systems for the analysis of genetic variation and biological function. Provides a line of products and services that serve the sequencing, genotyping and gene expression and proteomics markets. Its headquarters are located in San Diego, California.

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PeakRanger (tool)

RRID:SCR_010863

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GenomeStudio (tool)

RRID:SCR_010973

Visualize and analyze data generated by all of Illumina''s platforms.

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ChIP-seq (tool)

RRID:SCR_001237

Set of software modules for performing common ChIP-seq data analysis tasks across the whole genome, including positional correlation analysis, peak detection, and genome partitioning into signal-rich and signal-poor regions. The tools are designed to be simple, fast and highly modular. Each program carries out a well defined data processing procedure that can potentially fit into a pipeline framework. ChIP-Seq is also freely available on a Web interface.

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