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Longitudinal changes in dietary fat intake and associated changes in cardiovascular risk factors in adults with type 2 diabetes: the ACCORD trial.

AIMS: To measure dietary fat intake using the Puget Sound Eating Patterns (PEP) questionnaire, a validated 19-item food questionnaire, and to quantify how reduced dietary fat intake affects cardiovascular risk factors in adults with type 2 diabetes. METHODS: Randomized controlled trial including a subsample of 1781 Action to Control Cardiovascular Risk in Diabetes (ACCORD) participants. Participants received dietary counseling to consume a reduced-fat diet. Outcome measures included HbA1c, fasting lipid profile, blood pressure, and weight. Longitudinal linear regression analyses were used to evaluate relationships between baseline and follow-up PEP scores and cardiovascular risk factors. RESULTS: PEP scores decreased significantly from baseline to 12-month follow up with a mean difference of -0.09 ± 0.39, P<0.001. All of the fat intake subscales showed significant improvement at 12 months from baseline. White race, female gender, and more hours per week of physical activity were correlated with a decline in PEP scores at 1-year. A longitudinal decrease in dietary fat intake was associated with significantly less weight gain at 12- and 36-months and lower serum triglycerides at 1 year. CONCLUSIONS: Reduced fat intake as measured by a brief questionnaire was associated with significant improvement in some cardiovascular risk factors (triglycerides and weight), but not in others.

Pubmed ID: 23490598


  • Kirk JK
  • Craven T
  • Lipkin EW
  • Katula J
  • Pedley C
  • O'Connor PJ
  • Margolis KL


Diabetes research and clinical practice

Publication Data

April 23, 2013

Associated Grants

  • Agency: NHLBI NIH HHS, Id: IAA-Y1-HC-1010
  • Agency: NHLBI NIH HHS, Id: IAA-Y1-HC-9035
  • Agency: NHLBI NIH HHS, Id: N01-HC-95178
  • Agency: NHLBI NIH HHS, Id: N01-HC-95179
  • Agency: NHLBI NIH HHS, Id: N01-HC-95180
  • Agency: NHLBI NIH HHS, Id: N01-HC-95181
  • Agency: NHLBI NIH HHS, Id: N01-HC-95182
  • Agency: NHLBI NIH HHS, Id: N01-HC-95183
  • Agency: NHLBI NIH HHS, Id: N01-HC-95184
  • Agency: NHLBI NIH HHS, Id: N01HC95182
  • Agency: NIDDK NIH HHS, Id: P30 DK092924

Mesh Terms

  • Blood Glucose
  • Blood Pressure
  • Body Mass Index
  • Body Weight
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Diabetic Angiopathies
  • Dietary Fats
  • Energy Intake
  • Female
  • Hemoglobin A, Glycosylated
  • Humans
  • Linear Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Motor Activity
  • Patient Compliance
  • Patient Outcome Assessment
  • Questionnaires
  • United States
  • Weight Gain