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Dahl (S Ɨ R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp.

A quantitative trait locus (QTL) linked with ability to find a platform in the Morris Water Maze (MWM) was located on chromosome 17 (Nav-5 QTL) using intercross between Dahl S and Dahl R rats. We developed two congenic strains, S.R17A and S.R17B introgressing Dahl R-chromosome 17 segments into Dahl S chromosome 17 region spanning putative Nav-5 QTL. Performance analysis of S.R17A, S.R17B and Dahl S rats in the Morris water maze (MWM) task showed a significantly decreased spatial navigation performance in S.R17B congenic rats when compared with Dahl S controls (Pā€Š=ā€Š0.02). The S.R17A congenic segment did not affect MWM performance delimiting Nav-5 to the chromosome 17 65.02-74.66 Mbp region. Additional fine mapping is necessary to identify the specific gene variant accounting for Nav-5 effect on spatial learning and memory in Dahl rats.

Pubmed ID: 23469157


  • Herrera VL
  • Pasion KA
  • Tan GA
  • Ruiz-Opazo N


PloS one

Publication Data

March 7, 2013

Associated Grants

  • Agency: NHLBI NIH HHS, Id: R01 HL086532

Mesh Terms

  • Animals
  • Animals, Congenic
  • Chromosomes, Mammalian
  • Crosses, Genetic
  • Hybridization, Genetic
  • Male
  • Memory
  • Quantitative Trait Loci
  • Rats
  • Rats, Inbred Dahl
  • Spatial Behavior