Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

http://www.ncbi.nlm.nih.gov/pubmed/23454382

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

Pubmed ID: 23454382 RIS Download

Mesh terms: Amino Acid Sequence | Animals | Bicyclo Compounds | Carrier Proteins | Dose-Response Relationship, Drug | Embryo, Nonmammalian | Embryonic Development | Gene Expression Regulation, Developmental | Gene Knockdown Techniques | Mitochondria | Molecular Sequence Data | Morpholinos | Neovascularization, Physiologic | Prognosis | Vascular Endothelial Growth Factor A | Zebrafish

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NICHD NIH HHS, Id: DP1 HD075622
  • Agency: NCCDPHP CDC HHS, Id: DP1HD075622

ZFIN (Data, Gene Expression)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.