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'What's in the NIDDK CDR?'--public query tools for the NIDDK central data repository.

The National Institute of Diabetes and Digestive Disease (NIDDK) Central Data Repository (CDR) is a web-enabled resource available to researchers and the general public. The CDR warehouses clinical data and study documentation from NIDDK funded research, including such landmark studies as The Diabetes Control and Complications Trial (DCCT, 1983-93) and the Epidemiology of Diabetes Interventions and Complications (EDIC, 1994-present) follow-up study which has been ongoing for more than 20 years. The CDR also houses data from over 7 million biospecimens representing 2 million subjects. To help users explore the vast amount of data stored in the NIDDK CDR, we developed a suite of search mechanisms called the public query tools (PQTs). Five individual tools are available to search data from multiple perspectives: study search, basic search, ontology search, variable summary and sample by condition. PQT enables users to search for information across studies. Users can search for data such as number of subjects, types of biospecimens and disease outcome variables without prior knowledge of the individual studies. This suite of tools will increase the use and maximize the value of the NIDDK data and biospecimen repositories as important resources for the research community. Database URL: https://www.niddkrepository.org/niddk/home.do.

Pubmed ID: 23396299 RIS Download

Mesh terms: Databases as Topic | Female | Humans | Internet | Male | National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) | Search Engine | United States

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

NIDDKCentral Repository

Data, biosample, and genetic repositories to increase the impact of current and previously funded NIDDKstudies, making the data and biospecimens available to the broader scientific community. These Repositories enable scientists not involved in the original study to test new hypotheses without any new data or biospecimen collection, and provide the opportunity to pool data across several studies to increase the power of statistical analyses. In addition, most NIDDK-funded studies are collecting genetic biospecimens and carrying out high-throughput genotyping making it possible for other scientists to use Repository resources to match genotypes to phenotypes and to perform informative genetic analyses. There are three Repositories: * Biosample Repository - Fisher BioServices, Inc (14665 Rothgeb Drive, Rockville, MD 20850) Receives biosamples collected in many different studies, stores the samples under optimal conditions, and distributes them to qualified investigators. * Genetics Repository - Rutgers, The State University of New Jersey (Rutgers Lab)(604 Allison Road, Nelson Labs C112, Piscataway, NJ 08854) Receives blood samples collected in many different studies, and processes them to create immortalized cell lines, and DNA samples. They also cryopreserve blood cells, extract DNA from blood samples, store samples of DNA under optimal conditions, and distribute DNA samples to qualified investigators. * Central Data Repository (CDR) - RTI International (3040 Cornwallis Rd, Research Triangle Park, NC 27709) Receives, archives, maintains and distributes databases or parts of databases from studies. In addition, they analyze stored data in response to inquiries, assist ongoing studies in preparing data for eventual archiving, coordinate cross-referencing between the three Repositories, and maintain the Central Repository website. The NIDDKCentral Repositories have four major components: * An archive of clinical data and documentation from NIDDK-sponsored studies * A collection of biospecimens and an associated database that identifies specimens collected from ongoing and completed studies funded by NIDDKand links them to the associated phenotypic data * A web portal that makes study-specific information within the Repository easily viewable and that accepts electronic requests for biospecimens and data * A collection of genotyping data from GWAS and sequencing studies housed at the National Center for Biotechnology Information's (NCBI) database of Genotypes and Phenotypes (dbGaP)


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