Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling.

Cell | Nov 21, 2012

http://www.ncbi.nlm.nih.gov/pubmed/23178125

The origins and developmental mechanisms of coronary arteries are incompletely understood. We show here by fate mapping, clonal analysis, and immunohistochemistry that endocardial cells generate the endothelium of coronary arteries. Dye tracking, live imaging, and tissue transplantation also revealed that ventricular endocardial cells are not terminally differentiated; instead, they are angiogenic and form coronary endothelial networks. Myocardial Vegf-a or endocardial Vegfr-2 deletion inhibited coronary angiogenesis and arterial formation by ventricular endocardial cells. In contrast, lineage and knockout studies showed that endocardial cells make a small contribution to the coronary veins, the formation of which is independent of myocardial-to-endocardial Vegf signaling. Thus, contrary to the current view of a common source for the coronary vessels, our findings indicate that the coronary arteries and veins have distinct origins and are formed by different mechanisms. This information may help develop better cell therapies for coronary artery disease.

Pubmed ID: 23178125 RIS Download

Mesh terms: Animals | Cell Differentiation | Coronary Vessels | Endothelial Cells | Mice | Myocardium | NFATC Transcription Factors | Neovascularization, Physiologic | Signal Transduction | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factor Receptor-2

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NHLBI NIH HHS, Id: HL078881
  • Agency: NHLBI NIH HHS, Id: HL100398
  • Agency: NHLBI NIH HHS, Id: HL85345
  • Agency: NHLBI NIH HHS, Id: R01 HL078881

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.