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Nuclear aggregation of olfactory receptor genes governs their monogenic expression.

Cell | Nov 9, 2012

http://www.ncbi.nlm.nih.gov/pubmed/23141535

Gene positioning and regulation of nuclear architecture are thought to influence gene expression. Here, we show that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes converge in a small number of heterochromatic foci. These foci are OR exclusive and form in a cell-type-specific and differentiation-dependent manner. The aggregation of OR genes is developmentally synchronous with the downregulation of lamin b receptor (LBR) and can be reversed by ectopic expression of LBR in mature olfactory neurons. LBR-induced reorganization of nuclear architecture and disruption of OR aggregates perturbs the singularity of OR transcription and disrupts the targeting specificity of the olfactory neurons. Our observations propose spatial sequestering of heterochromatinized OR family members as a basis of monogenic and monoallelic gene expression.

Pubmed ID: 23141535 RIS Download

Mesh terms: Animals | Cell Nucleus | Chromosomal Proteins, Non-Histone | Down-Regulation | Gene Expression Regulation | Heterochromatin | In Situ Hybridization, Fluorescence | Mice | Olfactory Receptor Neurons | Receptors, Cytoplasmic and Nuclear | Receptors, Odorant | Transcription, Genetic

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Associated grants

  • Agency: NCRR NIH HHS, Id: 5P41RR019664-08
  • Agency: NIDA NIH HHS, Id: 5R01DA030320-02
  • Agency: NIMH NIH HHS, Id: 5R01MH086920
  • Agency: NIGMS NIH HHS, Id: 8 P41 GM103445-08
  • Agency: NIGMS NIH HHS, Id: P41 GM103445
  • Agency: NCRR NIH HHS, Id: P41 RR019664
  • Agency: NIDA NIH HHS, Id: R01 DA030320

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