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Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain.

Annals of neurology | 2012

Previously we reported that exposure of 6-day-old (P6) rhesus macaques to isoflurane for 5 hours triggers a robust neuroapoptosis response in developing brain. We have also observed (unpublished data) that isoflurane causes apoptosis of cellular profiles in the white matter that resemble glia. We analyzed the cellular identity of the apoptotic white matter profiles and determined the magnitude of this cell death response to isoflurane.

Pubmed ID: 23109147 RIS Download

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Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: R01 NS054044
  • Agency: NICHD NIH HHS, United States
    Id: HD 062171
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD052664
  • Agency: NINDS NIH HHS, United States
    Id: F30 NS066704
  • Agency: NICHD NIH HHS, United States
    Id: R01 HD037100
  • Agency: NCRR NIH HHS, United States
    Id: P51 RR000163
  • Agency: NICHD NIH HHS, United States
    Id: P30 HD062171
  • Agency: NINDS NIH HHS, United States
    Id: 1F30NS066704
  • Agency: NICHD NIH HHS, United States
    Id: HD 052664
  • Agency: NCRR NIH HHS, United States
    Id: RR-000163
  • Agency: NINDS NIH HHS, United States
    Id: 1R01NS054044
  • Agency: NCRR NIH HHS, United States
    Id: K01 RR000163
  • Agency: NINDS NIH HHS, United States
    Id: R37NS045737-06S1/06S2
  • Agency: NICHD NIH HHS, United States
    Id: HD37100
  • Agency: NINDS NIH HHS, United States
    Id: R37 NS045737
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS045737
  • Agency: NICHD NIH HHS, United States
    Id: R37 HD037100

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