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OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.

Nature neuroscience | 2012

The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types has been hampered by the lack of cell-specific tools. We identified a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining transgenic mice and optogenetic tools, we found that OLM cells are important for gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). Furthermore, we found that OLM cells were interconnected by gap junctions, received direct cholinergic inputs from subcortical afferents and accounted for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.

Pubmed ID: 23042082 RIS Download

Research resources used in this publication

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Antibodies used in this publication

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P41 RR000954
  • Agency: NIBIB NIH HHS, United States
    Id: R01 EB001963
  • Agency: NIBIB NIH HHS, United States
    Id: R01EB001963

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