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Epigenetic interplay between mouse endogenous retroviruses and host genes.

Genome biology | 2012

Transposable elements are often the targets of repressive epigenetic modifications such as DNA methylation that, in theory, have the potential to spread toward nearby genes and induce epigenetic silencing. To better understand the role of DNA methylation in the relationship between transposable elements and genes, we assessed the methylation state of mouse endogenous retroviruses (ERVs) located near genes.

Pubmed ID: 23034137 RIS Download

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Associated grants

  • Agency: Canadian Institutes of Health Research, Canada

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UCSC Genome Browser (tool)

RRID:SCR_005780

Portal to interactively visualize genomic data. Provides reference sequences and working draft assemblies for collection of genomes and access to ENCODE and Neanderthal projects. Includes collection of vertebrate and model organism assemblies and annotations, along with suite of tools for viewing, analyzing and downloading data.

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COBrA (tool)

RRID:SCR_005677

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129X1/SvJ (tool)

RRID:IMSR_JAX:000691

Mus musculus with name 129X1/SvJ from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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DBA/2J (tool)

RRID:IMSR_JAX:000671

Mus musculus with name DBA/2J from IMSR.

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