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oPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets.

oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at

Pubmed ID: 22973536


  • Kwon AT
  • Arenillas DJ
  • Worsley Hunt R
  • Wasserman WW


G3 (Bethesda, Md.)

Publication Data

September 13, 2012

Associated Grants

  • Agency: NIGMS NIH HHS, Id: 1R01GM084875
  • Agency: NIGMS NIH HHS, Id: R01 GM084875
  • Agency: Canadian Institutes of Health Research, Id:

Mesh Terms

  • Animals
  • Base Composition
  • Binding Sites
  • Chromatin Immunoprecipitation
  • Cilia
  • Computational Biology
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Internet
  • Muscle, Skeletal
  • Nematoda
  • Nucleotide Motifs
  • Regulatory Sequences, Nucleic Acid
  • Software
  • Transcription Factors