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The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A | Anastassiadis K | Ayadi A | Battey JF | Bell C | Birling MC | Bottomley J | Brown SD | Bürger A | Bult CJ | Bushell W | Collins FS | Desaintes C | Doe B | Economides A | Eppig JT | Finnell RH | Fletcher C | Fray M | Frendewey D | Friedel RH | Grosveld FG | Hansen J | Hérault Y | Hicks G | Hörlein A | Houghton R | Hrabé de Angelis M | Huylebroeck D | Iyer V | de Jong PJ | Kadin JA | Kaloff C | Kennedy K | Koutsourakis M | Lloyd KC | Marschall S | Mason J | McKerlie C | McLeod MP | von Melchner H | Moore M | Mujica AO | Nagy A | Nefedov M | Nutter LM | Pavlovic G | Peterson JL | Pollock J | Ramirez-Solis R | Rancourt DE | Raspa M | Remacle JE | Ringwald M | Rosen B | Rosenthal N | Rossant J | Ruiz Noppinger P | Ryder E | Schick JZ | Schnütgen F | Schofield P | Seisenberger C | Selloum M | Simpson EM | Skarnes WC | Smedley D | Stanford WL | Stewart AF | Stone K | Swan K | Tadepally H | Teboul L | Tocchini-Valentini GP | Valenzuela D | West AP | Yamamura K | Yoshinaga Y | Wurst W

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Pubmed ID: 22968824 RIS Download

Mesh terms: Animals | Internationality | Internet | Mice | Mice, Knockout

Research resources used in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NCRR NIH HHS, Id: U42 RR024244
  • Agency: NCI NIH HHS, Id: P30 CA093373
  • Agency: NHGRI NIH HHS, Id: U41 HG000330
  • Agency: NHGRI NIH HHS, Id: U54 HG006364
  • Agency: NIH HHS, Id: U42 OD012210
  • Agency: Medical Research Council, Id: MC_U142684172
  • Agency: NIH HHS, Id: U42 OD011175

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