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The mammalian gene function resource: the International Knockout Mouse Consortium.

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Pubmed ID: 22968824

Authors

  • Bradley A
  • Anastassiadis K
  • Ayadi A
  • Battey JF
  • Bell C
  • Birling MC
  • Bottomley J
  • Brown SD
  • Bürger A
  • Bult CJ
  • Bushell W
  • Collins FS
  • Desaintes C
  • Doe B
  • Economides A
  • Eppig JT
  • Finnell RH
  • Fletcher C
  • Fray M
  • Frendewey D
  • Friedel RH
  • Grosveld FG
  • Hansen J
  • Hérault Y
  • Hicks G
  • Hörlein A
  • Houghton R
  • Hrabé de Angelis M
  • Huylebroeck D
  • Iyer V
  • de Jong PJ
  • Kadin JA
  • Kaloff C
  • Kennedy K
  • Koutsourakis M
  • Lloyd KC
  • Marschall S
  • Mason J
  • McKerlie C
  • McLeod MP
  • von Melchner H
  • Moore M
  • Mujica AO
  • Nagy A
  • Nefedov M
  • Nutter LM
  • Pavlovic G
  • Peterson JL
  • Pollock J
  • Ramirez-Solis R
  • Rancourt DE
  • Raspa M
  • Remacle JE
  • Ringwald M
  • Rosen B
  • Rosenthal N
  • Rossant J
  • Ruiz Noppinger P
  • Ryder E
  • Schick JZ
  • Schnütgen F
  • Schofield P
  • Seisenberger C
  • Selloum M
  • Simpson EM
  • Skarnes WC
  • Smedley D
  • Stanford WL
  • Stewart AF
  • Stone K
  • Swan K
  • Tadepally H
  • Teboul L
  • Tocchini-Valentini GP
  • Valenzuela D
  • West AP
  • Yamamura K
  • Yoshinaga Y
  • Wurst W

Journal

Mammalian genome : official journal of the International Mammalian Genome Society

Publication Data

October 11, 2012

Associated Grants

  • Agency: Medical Research Council, Id: MC_U142684172
  • Agency: NHGRI NIH HHS, Id: U41 HG000330
  • Agency: NIH HHS, Id: U42 OD011175
  • Agency: NCRR NIH HHS, Id: U42 RR024244
  • Agency: NHGRI NIH HHS, Id: U54 HG006364

Mesh Terms

  • Animals
  • Internationality
  • Internet
  • Mice
  • Mice, Knockout