Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Spark: a navigational paradigm for genomic data exploration.

Genome research | Nov 5, 2012

Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources, and yet they are increasingly faced with nontrivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the early data exploration phases, we have developed an interactive pattern discovery and visualization approach, Spark, designed with epigenomic data in mind. Here we demonstrate Spark's ability to reveal both known and novel epigenetic signatures, including a previously unappreciated binding association between the YY1 transcription factor and the corepressor CTBP2 in human embryonic stem cells.

Pubmed ID: 22960372 RIS Download

Mesh terms: Alcohol Oxidoreductases | Cluster Analysis | DNA Methylation | Embryonic Stem Cells | Epigenesis, Genetic | Genome, Human | Humans | Nerve Tissue Proteins | Search Engine | Sequence Analysis, DNA | YY1 Transcription Factor

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NHGRI NIH HHS, Id: U54 HG004558
  • Agency: NIEHS NIH HHS, Id: U01 ES017154
  • Agency: NIDA NIH HHS, Id: U01 DA025956
  • Agency: Canadian Institutes of Health Research, Id: HG004558
  • Agency: NHGRI NIH HHS, Id: 5U01ES017154-02
  • Agency: NIEHS NIH HHS, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.