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Afadin is required for maintenance of dendritic structure and excitatory tone.

The dendritic field of a neuron, which is determined by both dendritic architecture and synaptic strength, defines the synaptic input of a cell. Once established, a neuron's dendritic field is thought to remain relatively stable throughout a cell's lifetime. Perturbations in a dendritic structure or excitatory tone of a cell and thus its dendritic field are cellular alterations thought to be correlated with a number of psychiatric disorders. Although several proteins are known to regulate the development of dendritic arborization, much less is known about the mechanisms that maintain dendritic morphology and synaptic strength. In this study, we find that afadin, a component of N-cadherin·β-catenin·α-N-catenin adhesion complexes, is required for the maintenance of established dendritic arborization and synapse number. We further demonstrate that afadin directly interacts with AMPA receptors and that loss of this protein reduces the surface expression of GluA1- and GluA2-AMPA receptor subunits. Collectively, these data suggest that afadin is required for the maintenance of dendritic structure and excitatory tone.

Pubmed ID: 22948147 RIS Download

Mesh terms: Animals | Cadherins | Cells, Cultured | Dendrites | Gene Expression Regulation | LIM Domain Proteins | Microfilament Proteins | Nerve Tissue Proteins | Rats | Rats, Sprague-Dawley | Receptors, AMPA | Synapses | alpha Catenin | beta Catenin

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Associated grants

  • Agency: NIMH NIH HHS, Id: F31 MH085362
  • Agency: NIMH NIH HHS, Id: MH097216
  • Agency: NIMH NIH HHS, Id: R01 MH097216
  • Agency: NINDS NIH HHS, Id: R01 NS044322
  • Agency: NIMH NIH HHS, Id: 1F31MH085362
  • Agency: NINDS NIH HHS, Id: R01 NS071952
  • Agency: NIA NIH HHS, Id: F31 AG031621
  • Agency: NICHD NIH HHS, Id: T32 HD040127
  • Agency: NIMH NIH HHS, Id: 1F31MH087043
  • Agency: NINDS NIH HHS, Id: NS44322
  • Agency: NIMH NIH HHS, Id: F31 MH087043
  • Agency: NIA NIH HHS, Id: 1F31AG031621
  • Agency: NIMH NIH HHS, Id: MH071316
  • Agency: NIMH NIH HHS, Id: R01 MH071316

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