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FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase.

Plant growth and development are controlled by a delicate balance of hormonal cues. Growth-promoting hormones and growth-inhibiting counterparts often antagonize each other in their action, but the molecular mechanisms underlying these events remain largely unknown. Here, we report a cross-talk mechanism that enables a receptor-like kinase, FERONIA (FER), a positive regulator of auxin-promoted growth, to suppress the abscisic acid (ABA) response through activation of ABI2, a negative regulator of ABA signaling. The FER pathway consists of a FER kinase interacting with guanine exchange factors GEF1, GEF4, and GEF10 that, in turn, activate GTPase ROP11/ARAC10. Arabidopsis mutants disrupted in any step of the FER pathway, including fer, gef1gef4gef10, or rop11/arac10, all displayed an ABA-hypersensitive response, implicating the FER pathway in the suppression mechanism. In search of the target for the FER pathway, we found that the ROP11/ARAC10 protein physically interacted with the ABI2 phosphatase and enhanced its activity, thereby linking the FER pathway with the inhibition of ABA signaling.

Pubmed ID: 22908257

Authors

  • Yu F
  • Qian L
  • Nibau C
  • Duan Q
  • Kita D
  • Levasseur K
  • Li X
  • Lu C
  • Li H
  • Hou C
  • Li L
  • Buchanan BB
  • Chen L
  • Cheung AY
  • Li D
  • Luan S

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Data

September 4, 2012

Associated Grants

None

Mesh Terms

  • Abscisic Acid
  • Arabidopsis
  • Arabidopsis Proteins
  • Cloning, Molecular
  • DNA Primers
  • Enzyme Activation
  • GTP-Binding Proteins
  • Gene Expression Profiling
  • Genetic Vectors
  • Glucuronidase
  • Microscopy, Fluorescence
  • Phosphoprotein Phosphatases
  • Phosphotransferases
  • Reactive Oxygen Species
  • Signal Transduction
  • Transformation, Genetic
  • rho GTP-Binding Proteins