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R-loops cause replication impairment and genome instability during meiosis.

EMBO reports | Oct 1, 2012

http://www.ncbi.nlm.nih.gov/pubmed/22878416

R-loops are harmful structures with a negative impact on transcription and recombination during mitosis, but no information exists for meiosis. We used Saccharomyces cerevisiae and Caenorhabditis elegans THO mutants as a tool to determine the consequences of R-loops in meiosis. We found that both S. cerevisiae and C. elegans THO mutants show defective meiosis and an impairment of premeiotic replication as well as DNA-damage accumulation. Importantly, RNase H partially suppressed the replication impairment and the DNA-damage accumulation. We conclude that R-loops can form during meiosis causing replication impairment with deleterious results.

Pubmed ID: 22878416 RIS Download

Mesh terms: Animals | Caenorhabditis elegans | Caenorhabditis elegans Proteins | DNA Damage | DNA Replication | DNA, Fungal | Genomic Instability | Meiosis | Nuclear Proteins | Ribonuclease H | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Transcription Factors