Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway.

http://www.ncbi.nlm.nih.gov/pubmed/22869749

Myostatin and activin A are structurally related secreted proteins that act to limit skeletal muscle growth. The cellular targets for myostatin and activin A in muscle and the role of satellite cells in mediating muscle hypertrophy induced by inhibition of this signaling pathway have not been fully elucidated. Here we show that myostatin/activin A inhibition can cause muscle hypertrophy in mice lacking either syndecan4 or Pax7, both of which are important for satellite cell function and development. Moreover, we show that muscle hypertrophy after pharmacological blockade of this pathway occurs without significant satellite cell proliferation and fusion to myofibers and without an increase in the number of myonuclei per myofiber. Finally, we show that genetic ablation of Acvr2b, which encodes a high-affinity receptor for myostatin and activin A specifically in myofibers is sufficient to induce muscle hypertrophy. All of these findings are consistent with satellite cells playing little or no role in myostatin/activin A signaling in vivo and render support that inhibition of this signaling pathway can be an effective therapeutic approach for increasing muscle growth even in disease settings characterized by satellite cell dysfunction.

Pubmed ID: 22869749 RIS Download

Mesh terms: Activin Receptors, Type II | Activins | Animals | Follistatin | Hypertrophy | Membrane Fusion | Mice | Mice, 129 Strain | Mice, Inbred C57BL | Mice, Transgenic | Muscle Fibers, Skeletal | Muscle, Skeletal | Myostatin | Organ Size | PAX7 Transcription Factor | Regeneration | Satellite Cells, Skeletal Muscle | Signal Transduction | Syndecan-4

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIH HHS, Id: DP5 OD009208
  • Agency: NIH HHS, Id: DP5OD009208
  • Agency: NINDS NIH HHS, Id: P01 NS072027
  • Agency: NINDS NIH HHS, Id: P01NS0720027
  • Agency: NIAMS NIH HHS, Id: R01 AR059685
  • Agency: NIAMS NIH HHS, Id: R01 AR060042
  • Agency: NIAMS NIH HHS, Id: R01 AR060636
  • Agency: NICHD NIH HHS, Id: R01 HD032067
  • Agency: NIAMS NIH HHS, Id: R01AR059685
  • Agency: NIAMS NIH HHS, Id: R01AR060042
  • Agency: NIAMS NIH HHS, Id: R01AR060636
  • Agency: NICHD NIH HHS, Id: R01HD032067

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.