We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Regional astrocyte allocation regulates CNS synaptogenesis and repair.

Science (New York, N.Y.) | Jul 20, 2012

Astrocytes, the most abundant cell population in the central nervous system (CNS), are essential for normal neurological function. We show that astrocytes are allocated to spatial domains in mouse spinal cord and brain in accordance with their embryonic sites of origin in the ventricular zone. These domains remain stable throughout life without evidence of secondary tangential migration, even after acute CNS injury. Domain-specific depletion of astrocytes in ventral spinal cord resulted in abnormal motor neuron synaptogenesis, which was not rescued by immigration of astrocytes from adjoining regions. Our findings demonstrate that region-restricted astrocyte allocation is a general CNS phenomenon and reveal intrinsic limitations of the astroglial response to injury.

Pubmed ID: 22745251 RIS Download

Mesh terms: Animals | Astrocytes | Bacterial Proteins | Basic Helix-Loop-Helix Transcription Factors | Brain | Brain Injuries | Cell Movement | Green Fluorescent Proteins | Homeodomain Proteins | Integrases | Luminescent Proteins | Mice | Mice, Transgenic | Motor Neurons | Nerve Tissue Proteins | Proteins | RNA, Untranslated | Spinal Cord | Spinal Cord Injuries | Synapses | Transcription Factors | Transcription, Genetic

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NINDS NIH HHS, Id: R01 NS028478
  • Agency: European Research Council, Id: 207807
  • Agency: Medical Research Council, Id: G0800575
  • Agency: Medical Research Council, Id: G0501173
  • Agency: Medical Research Council, Id: R37 HD032116
  • Agency: Howard Hughes Medical Institute, Id:
  • Agency: NICHD NIH HHS, Id:
  • Agency: Wellcome Trust, Id:

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.