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Ume6 transcription factor is part of a signaling cascade that regulates autophagy.

Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.

Pubmed ID: 22733735


  • Bartholomew CR
  • Suzuki T
  • Du Z
  • Backues SK
  • Jin M
  • Lynch-Day MA
  • Umekawa M
  • Kamath A
  • Zhao M
  • Xie Z
  • Inoki K
  • Klionsky DJ


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

July 10, 2012

Associated Grants

  • Agency: NIDDK NIH HHS, Id: DK083491
  • Agency: NIGMS NIH HHS, Id: GM53396
  • Agency: NIDDK NIH HHS, Id: R01 DK083491
  • Agency: NIGMS NIH HHS, Id: R01 GM053396

Mesh Terms

  • Autophagy
  • Gene Deletion
  • HeLa Cells
  • Histone Deacetylases
  • Humans
  • Lysosomes
  • Microtubule-Associated Proteins
  • Models, Biological
  • Models, Genetic
  • Promoter Regions, Genetic
  • Protein Kinases
  • Repressor Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Signal Transduction
  • Sin3 Histone Deacetylase and Corepressor Complex
  • Transcription, Genetic
  • Vacuoles