We have updated our privacy policy. If you have any question, contact us at privacy@scicrunch.org. Dismiss and don't show again

Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Ume6 transcription factor is part of a signaling cascade that regulates autophagy.

Autophagy has been implicated in a number of physiological processes important for human heath and disease. Autophagy involves the formation of a double-membrane cytosolic vesicle, an autophagosome. Central to the formation of the autophagosome is the ubiquitin-like protein autophagy-related (Atg)8 (microtubule-associated protein 1 light chain 3/LC3 in mammalian cells). Following autophagy induction, Atg8 shows the greatest change in expression of any of the proteins required for autophagy. The magnitude of autophagy is, in part, controlled by the amount of Atg8; thus, controlling Atg8 protein levels is one potential mechanism for modulating autophagy activity. We have identified a negative regulator of ATG8 transcription, Ume6, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels; deletion of any of these components leads to an increase in Atg8 and a concomitant increase in autophagic activity. A similar regulatory mechanism is present in mammalian cells, indicating that this process is highly conserved.

Pubmed ID: 22733735 RIS Download

Mesh terms: Autophagy | Autophagy-Related Protein 8 Family | Gene Deletion | HeLa Cells | Histone Deacetylases | Humans | Lysosomes | Microtubule-Associated Proteins | Models, Biological | Models, Genetic | Promoter Regions, Genetic | Protein Kinases | Repressor Proteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Signal Transduction | Sin3 Histone Deacetylase and Corepressor Complex | Transcription, Genetic | Vacuoles

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

Associated grants

  • Agency: NIDDK NIH HHS, Id: R01 DK083491
  • Agency: NIGMS NIH HHS, Id: R01 GM053396
  • Agency: NIDDK NIH HHS, Id: DK083491
  • Agency: NIGMS NIH HHS, Id: GM53396

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.