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A framework for human microbiome research.

Nature | Jun 13, 2012

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a broad range of quality-controlled resources and data including standardized methods for creating, processing and interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies.

Pubmed ID: 22699610 RIS Download

Mesh terms: Adolescent | Adult | Bacteria | Female | Humans | Male | Metagenome | Metagenomics | RNA, Ribosomal, 16S | Reference Standards | Statistics as Topic | Young Adult

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Associated grants

  • Agency: NHGRI NIH HHS, Id: N01HG62088
  • Agency: NHGRI NIH HHS, Id: R01 HG004857
  • Agency: NHGRI NIH HHS, Id: U54 HG004973
  • Agency: NIDCR NIH HHS, Id: U01DE016937
  • Agency: NIDCR NIH HHS, Id: RC1DE020298
  • Agency: NIAMS NIH HHS, Id: UH2 AR057504
  • Agency: NHGRI NIH HHS, Id: U54HG004969
  • Agency: NIAID NIH HHS, Id: T32 AI007528
  • Agency: NHGRI NIH HHS, Id: R01HG004856
  • Agency: NHGRI NIH HHS, Id: R01HG004908
  • Agency: NHGRI NIH HHS, Id: U54 HG003067
  • Agency: NHGRI NIH HHS, Id: U54HG003273
  • Agency: NHGRI NIH HHS, Id: R01HG004877
  • Agency: NIDCR NIH HHS, Id: P30DE020751
  • Agency: NHGRI NIH HHS, Id: R21HG005811
  • Agency: NHGRI NIH HHS, Id: R01 HG004900
  • Agency: NIH HHS, Id: DP2OD001500
  • Agency: NHGRI NIH HHS, Id: R01HG004885
  • Agency: NHGRI NIH HHS, Id: R01HG004872
  • Agency: NHGRI NIH HHS, Id: R01 HG004856
  • Agency: NHGRI NIH HHS, Id: R01 HG005171
  • Agency: NIAID NIH HHS, Id: UH3AI083263
  • Agency: NIAMS NIH HHS, Id: UH2 AR057506
  • Agency: NIAMS NIH HHS, Id: UH2AR057504
  • Agency: NHGRI NIH HHS, Id: U01HG004866
  • Agency: NHGRI NIH HHS, Id: U54HG003067
  • Agency: NIAID NIH HHS, Id: U54 AI084844
  • Agency: NIAMS NIH HHS, Id: UH3AR057504
  • Agency: NHGRI NIH HHS, Id: U54 HG003273
  • Agency: NIAID NIH HHS, Id: UH2AI083263
  • Agency: NHGRI NIH HHS, Id: U01 HG004866
  • Agency: NIAID NIH HHS, Id: U54AI084844
  • Agency: NHGRI NIH HHS, Id: R01 HG005975
  • Agency: NIDCR NIH HHS, Id: R37 DE016937
  • Agency: NIDDK NIH HHS, Id: UH3 DK083993
  • Agency: NIDCR NIH HHS, Id: R01DE021574
  • Agency: NHGRI NIH HHS, Id: R01 HG004885
  • Agency: NHGRI NIH HHS, Id: U54 HG004968
  • Agency: NHGRI NIH HHS, Id: U54HG004973
  • Agency: NIAID NIH HHS, Id: UH2 AI083263
  • Agency: NHGRI NIH HHS, Id: R01HG005171
  • Agency: NIAID NIH HHS, Id: T32AI007528
  • Agency: NHGRI NIH HHS, Id: R01HG004906
  • Agency: NHGRI NIH HHS, Id: U54HG003079
  • Agency: NIDCR NIH HHS, Id: R01 DE021574
  • Agency: NIDCR NIH HHS, Id: RC1 DE020298
  • Agency: NIH HHS, Id: DP2 OD001500
  • Agency: NHGRI NIH HHS, Id: R01HG005172
  • Agency: NIDDK NIH HHS, Id: UH3DK083993
  • Agency: NHGRI NIH HHS, Id: R01 HG004908
  • Agency: NHGRI NIH HHS, Id: R01 HG004872
  • Agency: NCI NIH HHS, Id: R21 CA139193
  • Agency: NHGRI NIH HHS, Id: R01HG005975
  • Agency: NIDCR NIH HHS, Id: U01 DE016937
  • Agency: Howard Hughes Medical Institute, Id: R01 HG005969
  • Agency: NHGRI NIH HHS, Id: R21CA139193
  • Agency: NCI NIH HHS, Id: R21 HG005811
  • Agency: NHGRI NIH HHS, Id: U54 HG003079
  • Agency: NHGRI NIH HHS, Id: R01 HG004853
  • Agency: NHGRI NIH HHS, Id: N01AI30071
  • Agency: NIAID NIH HHS, Id: U54 HG004969
  • Agency: NHGRI NIH HHS, Id: R01HG00485
  • Agency: NHGRI NIH HHS, Id: R01HG004853
  • Agency: NHGRI NIH HHS, Id: UH3 AI083263
  • Agency: NIAID NIH HHS, Id: UH2DK083990
  • Agency: NIDDK NIH HHS, Id: U54HG004968
  • Agency: NHGRI NIH HHS, Id: R01 HG004906
  • Agency: NHGRI NIH HHS, Id: R01HG005969
  • Agency: NHGRI NIH HHS, Id: R01 HG004877
  • Agency: NHGRI NIH HHS, Id: P30 DE020751
  • Agency: NIDCR NIH HHS, Id: R01 HG005172
  • Agency: NHGRI NIH HHS, Id: UH2AR057506
  • Agency: NIAMS NIH HHS, Id: R01HG004900
  • Agency: NHGRI NIH HHS, Id: UH2 DK083990
  • Agency: NIDDK NIH HHS, Id:

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Common repository for diverse human microbiome datsets and minimum reporting standards for Common Fund Human Microbiome Project.

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