• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression.

Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in yeast, is a nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylase that belongs to the family of HDAC class III sirtuins. Importantly, SIRT1 has been shown to play a critical role in synaptic plasticity and memory formation. This study reveals a functional interplay between two critical epigenetic regulators, MeCP2 and SIRT1, which controls MeCP2 binding activity to the brain-derived neurotrophic factor (BDNF) promoter in a specific region of the brain.

Pubmed ID: 22677942

Authors

  • Zocchi L
  • Sassone-Corsi P

Journal

Epigenetics

Publication Data

July 20, 2012

Associated Grants

None

Mesh Terms

  • Acetylation
  • Animals
  • Brain-Derived Neurotrophic Factor
  • Lysine
  • Methyl-CpG-Binding Protein 2
  • Mice
  • Mice, Mutant Strains
  • Mutation
  • Neurons
  • Sirtuin 1
  • p300-CBP Transcription Factors