SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression.
Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in yeast, is a nicotinamide-adenine dinucleotide (NAD(+))-dependent histone deacetylase that belongs to the family of HDAC class III sirtuins. Importantly, SIRT1 has been shown to play a critical role in synaptic plasticity and memory formation. This study reveals a functional interplay between two critical epigenetic regulators, MeCP2 and SIRT1, which controls MeCP2 binding activity to the brain-derived neurotrophic factor (BDNF) promoter in a specific region of the brain.
Pubmed ID: 22677942 RIS Download
Acetylation | Animals | Brain-Derived Neurotrophic Factor | Lysine | Methyl-CpG-Binding Protein 2 | Mice | Mice, Mutant Strains | Mutation | Neurons | Sirtuin 1 | p300-CBP Transcription Factors