• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Activity regulates functional connectivity from the vomeronasal organ to the accessory olfactory bulb.

The mammalian accessory olfactory system is specialized for the detection of chemicals that identify kin and conspecifics. Vomeronasal sensory neurons (VSNs) residing in the vomeronasal organ project axons to the accessory olfactory bulb (AOB), where they form synapses with principal neurons known as mitral cells. The organization of this projection is quite precise and is believed to be essential for appropriate function of this system. However, how this precise connectivity is established is unknown. We show here that in mice the vomeronasal duct is open at birth, allowing external chemical stimuli access to sensory neurons, and that these sensory neurons are capable of releasing neurotransmitter to downstream neurons as early as the first postnatal day (P). Using major histocompatibility complex class I peptides to activate a selective subset of VSNs during the first few postnatal days of development, we show that increased activity results in exuberant VSN axonal projections and a delay in axonal coalescence into well defined glomeruli in the AOB. Finally, we show that mitral cell dendritic refinement occurs just after the coalescence of presynaptic axons. Such a mechanism may allow the formation of precise connectivity with specific glomeruli that receive input from sensory neurons expressing the same receptor type.

Pubmed ID: 22674266


  • Hovis KR
  • Ramnath R
  • Dahlen JE
  • Romanova AL
  • LaRocca G
  • Bier ME
  • Urban NN


The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

June 6, 2012

Associated Grants

  • Agency: NIDCD NIH HHS, Id: F31 DC009376
  • Agency: NIDCD NIH HHS, Id: F31 DC009376-01
  • Agency: NIDCD NIH HHS, Id: R01 DC005798
  • Agency: NIDCD NIH HHS, Id: R01 DC005798-01
  • Agency: NIDCD NIH HHS, Id: R01 DC011184
  • Agency: NIDCD NIH HHS, Id: R21 DC006631
  • Agency: NIDCD NIH HHS, Id: R21 DC006631-01

Mesh Terms

  • Animals
  • Axons
  • Dendrites
  • Electroporation
  • Female
  • Freeze Drying
  • Gene Expression
  • Genes, MHC Class I
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Transgenic
  • Microscopy, Confocal
  • Neural Pathways
  • Neuropeptides
  • Olfactory Bulb
  • Olfactory Receptor Neurons
  • Patch-Clamp Techniques
  • Proto-Oncogene Proteins c-fos
  • Receptors, Presynaptic
  • Smell
  • Vomeronasal Organ