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Stimulant abuser groups to engage in 12-step: a multisite trial in the National Institute on Drug Abuse Clinical Trials Network.

AIMS: The study evaluated the effectiveness of an 8-week combined group plus individual 12-step facilitative intervention on stimulant drug use and 12-step meeting attendance and service. DESIGN: Multisite randomized controlled trial, with assessments at baseline, mid-treatment, end of treatment, and 3- and 6-month post-randomization follow-ups (FUs). SETTING: Intensive outpatient substance treatment programs. PARTICIPANTS: Individuals with stimulant use disorders (n = 471) randomly assigned to treatment as usual (TAU) or TAU into which the Stimulant Abuser Groups to Engage in 12-Step (STAGE-12) intervention was integrated. MEASUREMENTS: Urinalysis and self-reports of substance use and 12-step attendance and activities. INTERVENTION: Group sessions focused on increasing acceptance of 12-step principles; individual sessions incorporated an intensive referral procedure connecting participants to 12-step volunteers. FINDINGS: Compared with TAU, STAGE-12 participants had significantly greater odds of self-reported stimulant abstinence during the active 8-week treatment phase; however, among those who had not achieved abstinence during this period, STAGE-12 participants had more days of use. STAGE-12 participants had lower Addiction Severity Index Drug Composite scores at and a significant reduction from baseline to the 3-month FU, attended 12-step meetings on a greater number of days during the early phase of active treatment, engaged in more other types of 12-step activities throughout the active treatment phase and the entire FU period, and had more days of self-reported service at meetings from mid-treatment through the 6-month FU. CONCLUSIONS: The present findings are mixed with respect to the impact of integrating the STAGE-12 intervention into intensive outpatient drug treatment compared with TAU on stimulant drug use. However, the results more clearly indicate that individuals in STAGE-12 had higher rates of 12-step meeting attendance and were engaged in more related activities throughout both the active treatment phase and the entire 6-month FU period than did those in TAU.

Pubmed ID: 22657748


  • Donovan DM
  • Daley DC
  • Brigham GS
  • Hodgkins CC
  • Perl HI
  • Garrett SB
  • Doyle SR
  • Floyd AS
  • Knox PC
  • Botero C
  • Kelly TM
  • Killeen TK
  • Hayes C
  • Kau'i Baumhofer N
  • Kau'ibaumhofer N
  • Seamans C
  • Zammarelli L


Journal of substance abuse treatment

Publication Data

January 26, 2013

Associated Grants

  • Agency: NIDA NIH HHS, Id: U10 DA013714
  • Agency: NIDA NIH HHS, Id: U10 DA020024
  • Agency: NIDA NIH HHS, Id: U10DA13036
  • Agency: NIDA NIH HHS, Id: U10DA13045
  • Agency: NIDA NIH HHS, Id: U10DA13714
  • Agency: NIDA NIH HHS, Id: U10DA13720
  • Agency: NIDA NIH HHS, Id: U10DA13727
  • Agency: NIDA NIH HHS, Id: U10DA13732
  • Agency: NIDA NIH HHS, Id: U10DA20024
  • Agency: NIDA NIH HHS, Id: U10DA20036

Mesh Terms

  • Adult
  • Central Nervous System Stimulants
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • National Institute on Drug Abuse (U.S.)
  • Patient Compliance
  • Recurrence
  • Referral and Consultation
  • Self-Help Groups
  • Severity of Illness Index
  • Substance Abuse Detection
  • Substance-Related Disorders
  • Time Factors
  • Treatment Outcome
  • United States