• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Acetyl-CoA carboxylase regulates global histone acetylation.

Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and synthesis of fatty acids compete for the same acetyl-CoA pool. The first and rate-limiting reaction in de novo synthesis of fatty acids is carboxylation of acetyl-CoA to form malonyl-CoA, catalyzed by acetyl-CoA carboxylase. In yeast Saccharomyces cerevisiae, acetyl-CoA carboxylase is encoded by the ACC1 gene. In this study, we show that attenuated expression of ACC1 results in increased acetylation of bulk histones, globally increased acetylation of chromatin histones, and altered transcriptional regulation. Together, our data indicate that Acc1p activity regulates the availability of acetyl-CoA for histone acetyltransferases, thus representing a link between intermediary metabolism and epigenetic mechanisms of transcriptional regulation.

Pubmed ID: 22580297

Authors

  • Galdieri L
  • Vancura A

Journal

The Journal of biological chemistry

Publication Data

July 6, 2012

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM087674

Mesh Terms

  • Acetyl-CoA Carboxylase
  • Acetylation
  • Blotting, Western
  • Chromatin
  • Doxycycline
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Fungal
  • Histone Acetyltransferases
  • Histones
  • Mutation
  • Reverse Transcriptase Polymerase Chain Reaction
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins