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An MRI study of amygdala in schizophrenia and psychotic bipolar disorder.

Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p=0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia.

Pubmed ID: 22559949

Authors

  • Mahon PB
  • Eldridge H
  • Crocker B
  • Notes L
  • Gindes H
  • Postell E
  • King S
  • Potash JB
  • Ratnanather JT
  • Barta PE

Journal

Schizophrenia research

Publication Data

July 11, 2012

Associated Grants

  • Agency: NIBIB NIH HHS, Id: P41 EB015909
  • Agency: NCRR NIH HHS, Id: P41 RR015241
  • Agency: NCRR NIH HHS, Id: P41 RR015241
  • Agency: NCRR NIH HHS, Id: P41 RR015241-01A1
  • Agency: NIBIB NIH HHS, Id: R01 EB000975
  • Agency: NIBIB NIH HHS, Id: R01 EB000975
  • Agency: NIBIB NIH HHS, Id: R01 EB000975-01
  • Agency: NIMH NIH HHS, Id: R01 MH064838
  • Agency: NIMH NIH HHS, Id: R01 MH064838
  • Agency: NIMH NIH HHS, Id: R01 MH064838-04

Mesh Terms

  • Adult
  • Amygdala
  • Bipolar Disorder
  • Case-Control Studies
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Schizophrenia