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Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate.

Neural development | 2012

In the developing vertebrate nervous system elevated levels of Notch signaling activity can block neurogenesis and promote formation of glial cells. The mechanisms that limit Notch activity to balance formation of neurons and glia from neural precursors are poorly understood.

Pubmed ID: 22554084 RIS Download

Associated grants

  • Agency: NICHD NIH HHS, United States
    Id: T32 HD007502
  • Agency: NINDS NIH HHS, United States
    Id: P30 NS048154
  • Agency: NINDS NIH HHS, United States
    Id: NS046668

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Zebrafish Information Network (ZFIN) (tool)

RRID:SCR_002560

Model organism database that serves as central repository and web-based resource for zebrafish genetic, genomic, phenotypic and developmental data. Data represented are derived from three primary sources: curation of zebrafish publications, individual research laboratories and collaborations with bioinformatics organizations. Data formats include text, images and graphical representations.Serves as primary community database resource for laboratory use of zebrafish. Developed and supports integrated zebrafish genetic, genomic, developmental and physiological information and link this information extensively to corresponding data in other model organism and human databases.

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Volocity 3D Image Analysis Software (tool)

RRID:SCR_002668

3D image analysis software to visualize, analyze and validate 3D fluorescence images from a wide range of confocal microscopy, widefield and high content screening systems. It is fully integrated for a seamless user experience.

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Anti-SOX2 antibody (antibody)

RRID:AB_2341193

This polyclonal targets sox2

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