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Key observations from the NHLBI Asthma Clinical Research Network.

The National Heart, Lung and Blood Institute (NHLBI) Asthma Clinical Research Network (ACRN) recently completed its work after 20 years of collaboration as a multicentre clinical trial network. When formed, its stated mission was to perform multiple controlled clinical trials for treating patients with asthma by dispassionately examining new and existing therapies, and to rapidly communicate its findings to the medical community. The ACRN conducted 15 major clinical trials. In addition, clinical data, manual of operations, protocols and template informed consents from all ACRN trials are available via NHLBI BioLINCC (https://biolincc.nhlbi.nih.gov/studies/). This network contributed major insights into the use of inhaled corticosteroids, short-acting and long-acting ß-adrenergic agonists, leukotriene receptor antagonists, and novel agents (tiotropium, colchicine and macrolide antibiotics). They also pioneered studies of the variability in drug response, predictors of treatment response and pharmacogenetics. This review highlights the major research observations from the ACRN that have impacted the current management of asthma.

Pubmed ID: 22514237

Authors

  • Szefler SJ
  • Chinchilli VM
  • Israel E
  • Denlinger LC
  • Lemanske RF
  • Calhoun W
  • Peters SP
  • National Heart, Lung and Blood Institute Asthma Clinical Research Network

Journal

Thorax

Publication Data

May 19, 2012

Associated Grants

  • Agency: NHLBI NIH HHS, Id: U10 HL051810
  • Agency: NHLBI NIH HHS, Id: U10 HL051831
  • Agency: NHLBI NIH HHS, Id: U10 HL051834
  • Agency: NHLBI NIH HHS, Id: U10 HL051843
  • Agency: NHLBI NIH HHS, Id: U10 HL051845
  • Agency: NHLBI NIH HHS, Id: U10 HL051845
  • Agency: NHLBI NIH HHS, Id: U10 HL056443
  • Agency: NHLBI NIH HHS, Id: U10 HL074073
  • Agency: NHLBI NIH HHS, Id: U10 HL074204
  • Agency: NHLBI NIH HHS, Id: U10 HL074206
  • Agency: NHLBI NIH HHS, Id: U10 HL074208
  • Agency: NHLBI NIH HHS, Id: U10 HL074212
  • Agency: NHLBI NIH HHS, Id: U10 HL074218
  • Agency: NHLBI NIH HHS, Id: U10 HL074225
  • Agency: NHLBI NIH HHS, Id: U10 HL074227
  • Agency: NHLBI NIH HHS, Id: U10 HL074231
  • Agency: NHLBI NIH HHS, Id: U10 HL074231
  • Agency: NHLBI NIH HHS, Id: U10HL051823

Mesh Terms

  • Administration, Inhalation
  • Adrenal Cortex Hormones
  • Adrenergic beta-Agonists
  • Asthma
  • Biological Markers
  • Biomedical Research
  • Bronchodilator Agents
  • Humans
  • Macrolides
  • Scopolamine Derivatives