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Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or 'LCH cells'. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma. Here we confirm their findings and report the identification of two novel B-RAF mutations detected in LCH patients.
Pubmed ID: 22506009 RIS Download
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A multiple sequence alignment server which can align Protein, DNA and RNA sequences.
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View all literature mentionsCell line THP-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
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