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Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients.

PloS one | 2012

Dendritic cell (DC) vaccines have recently emerged as an innovative therapeutic option for glioblastoma patients. To identify novel surrogates of anti-tumor immune responsiveness, we studied the dynamic expression of activation and inhibitory markers on peripheral blood lymphocyte (PBL) subsets in glioblastoma patients treated with DC vaccination at UCLA.

Pubmed ID: 22485134 RIS Download

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: UL1 RR033176
  • Agency: NCI NIH HHS, United States
    Id: CA16042
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR000124
  • Agency: NCI NIH HHS, United States
    Id: R01 CA123396
  • Agency: NCI NIH HHS, United States
    Id: K01-CA111402
  • Agency: NCI NIH HHS, United States
    Id: P30 CA016042
  • Agency: NCI NIH HHS, United States
    Id: R01 CA 112358
  • Agency: NCI NIH HHS, United States
    Id: K01 CA111402
  • Agency: NCI NIH HHS, United States
    Id: R01 CA112358
  • Agency: NCI NIH HHS, United States
    Id: R01-CA123396

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ClinicalTrials.gov (tool)

RRID:SCR_002309

Registry and results database of federally and privately supported clinical trials conducted in United States and around world. Provides information about purpose of trial, who may participate, locations, and phone numbers for more details. This information should be used in conjunction with advice from health care professionals.Offers information for locating federally and privately supported clinical trials for wide range of diseases and conditions. Research study in human volunteers to answer specific health questions. Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings. ClinicalTrials.gov contains trials sponsored by National Institutes of Health, other federal agencies, and private industry. Studies listed in database are conducted in all 50 States and in 178 countries.

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