Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.

The nature and site of tumor-antigen presentation to immune T cells by bone-marrow-derived cells within the tumor microenvironment remains unresolved. We generated a fluorescent mouse model of spontaneous immunoevasive breast cancer and identified a subset of myeloid cells with significant similarity to dendritic cells and macrophages that constitutively ingest tumor-derived proteins and present processed tumor antigens to reactive T cells. Using intravital live imaging, we determined that infiltrating tumor-specific T cells engage in long-lived interactions with these cells, proximal to the tumor. In vitro, these cells capture cytotoxic T cells in signaling-competent conjugates but do not support full activation or sustain cytolysis. The spatiotemporal dynamics revealed here implicate nonproductive interactions between T cells and antigen-presenting cells on the tumor margin.

Pubmed ID: 22439936


  • Engelhardt JJ
  • Boldajipour B
  • Beemiller P
  • Pandurangi P
  • Sorensen C
  • Werb Z
  • Egeblad M
  • Krummel MF


Cancer cell

Publication Data

March 20, 2012

Associated Grants

  • Agency: NCI NIH HHS, Id: CA108462
  • Agency: NCI NIH HHS, Id: R01 CA134622
  • Agency: NCI NIH HHS, Id: R01 CA134622-01A1
  • Agency: NCI NIH HHS, Id: R01CA129523
  • Agency: NCI NIH HHS, Id: R01CA134622
  • Agency: NCI NIH HHS, Id: U01 CA141451
  • Agency: NCI NIH HHS, Id: U01 CA141451-01
  • Agency: NCI NIH HHS, Id: U01CA141451

Mesh Terms

  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm
  • Breast Neoplasms
  • Cross-Priming
  • Dendritic Cells
  • Female
  • Humans
  • Lymphocyte Activation
  • Mice
  • Myeloid Cells
  • T-Lymphocytes
  • Tumor Microenvironment