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Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.

The nature and site of tumor-antigen presentation to immune T cells by bone-marrow-derived cells within the tumor microenvironment remains unresolved. We generated a fluorescent mouse model of spontaneous immunoevasive breast cancer and identified a subset of myeloid cells with significant similarity to dendritic cells and macrophages that constitutively ingest tumor-derived proteins and present processed tumor antigens to reactive T cells. Using intravital live imaging, we determined that infiltrating tumor-specific T cells engage in long-lived interactions with these cells, proximal to the tumor. In vitro, these cells capture cytotoxic T cells in signaling-competent conjugates but do not support full activation or sustain cytolysis. The spatiotemporal dynamics revealed here implicate nonproductive interactions between T cells and antigen-presenting cells on the tumor margin.

Pubmed ID: 22439936


  • Engelhardt JJ
  • Boldajipour B
  • Beemiller P
  • Pandurangi P
  • Sorensen C
  • Werb Z
  • Egeblad M
  • Krummel MF


Cancer cell

Publication Data

March 20, 2012

Associated Grants

  • Agency: NCI NIH HHS, Id: CA108462
  • Agency: NCI NIH HHS, Id: R01 CA134622
  • Agency: NCI NIH HHS, Id: R01 CA134622-01A1
  • Agency: NCI NIH HHS, Id: R01CA129523
  • Agency: NCI NIH HHS, Id: R01CA134622
  • Agency: NCI NIH HHS, Id: U01 CA141451
  • Agency: NCI NIH HHS, Id: U01 CA141451-01
  • Agency: NCI NIH HHS, Id: U01CA141451

Mesh Terms

  • Animals
  • Antigen Presentation
  • Antigens, Neoplasm
  • Breast Neoplasms
  • Cross-Priming
  • Dendritic Cells
  • Female
  • Humans
  • Lymphocyte Activation
  • Mice
  • Myeloid Cells
  • T-Lymphocytes
  • Tumor Microenvironment