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Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.

General transcription factor TFIIH, previously described as a 10-subunit complex, is essential for transcription and DNA repair. An eleventh subunit now identified, termed Tfb6, exhibits 45% sequence similarity to human nuclear mRNA export factor 5. Tfb6 dissociates from TFIIH as a heterodimer with the Ssl2 subunit, a DNA helicase that drives promoter melting for the initiation of transcription. Tfb6 does not, however, dissociate Ssl2 from TFIIH in the context of a fully assembled transcription preinitiation complex. Our findings suggest a dynamic state of Ssl2, allowing its engagement in multiple cellular processes.

Pubmed ID: 22411836 RIS Download

Mesh terms: Chromatography, Liquid | DNA Helicases | Gene Deletion | Gene Expression Regulation, Fungal | Humans | Mass Spectrometry | Phenotype | Phosphorylation | Protein Binding | Protein Subunits | RNA, Messenger | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Temperature | Transcription Factor TFIIH | Transcription Factors | Transcription, Genetic | Ultraviolet Rays

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM036659
  • Agency: NIAID NIH HHS, Id: R01 AI021144
  • Agency: NIGMS NIH HHS, Id: R37 GM036659
  • Agency: NIGMS NIH HHS, Id: R01 GM097260
  • Agency: NIAID NIH HHS, Id: AI21144
  • Agency: NIGMS NIH HHS, Id: GM36659

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