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Fast gapped-read alignment with Bowtie 2.

Nature methods | Mar 4, 2012

As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.

Pubmed ID: 22388286 RIS Download

Mesh terms: Algorithms | Computational Biology | Databases, Genetic | Genome, Human | Humans | Sequence Alignment | Sequence Analysis, DNA

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Associated grants

  • Agency: NHGRI NIH HHS, Id: R01 HG006677
  • Agency: NHGRI NIH HHS, Id: R01-HG006102
  • Agency: NHGRI NIH HHS, Id: R01 HG006102-02
  • Agency: NHGRI NIH HHS, Id: R01 HG006677-12
  • Agency: NIGMS NIH HHS, Id: R01 GM083873
  • Agency: NHGRI NIH HHS, Id: R01 HG006102-01
  • Agency: NHGRI NIH HHS, Id: R01 HG006102
  • Agency: NHGRI NIH HHS, Id: R01 HG006677-13
  • Agency: NIGMS NIH HHS, Id: R01-GM083873

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