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The Human Connectome Project: a data acquisition perspective.


The Human Connectome Project (HCP) is an ambitious 5-year effort to characterize brain connectivity and function and their variability in healthy adults. This review summarizes the data acquisition plans being implemented by a consortium of HCP investigators who will study a population of 1200 subjects (twins and their non-twin siblings) using multiple imaging modalities along with extensive behavioral and genetic data. The imaging modalities will include diffusion imaging (dMRI), resting-state fMRI (R-fMRI), task-evoked fMRI (T-fMRI), T1- and T2-weighted MRI for structural and myelin mapping, plus combined magnetoencephalography and electroencephalography (MEG/EEG). Given the importance of obtaining the best possible data quality, we discuss the efforts underway during the first two years of the grant (Phase I) to refine and optimize many aspects of HCP data acquisition, including a new 7T scanner, a customized 3T scanner, and improved MR pulse sequences.

Pubmed ID: 22366334


  • Van Essen DC
  • Ugurbil K
  • Auerbach E
  • Barch D
  • Behrens TE
  • Bucholz R
  • Chang A
  • Chen L
  • Corbetta M
  • Curtiss SW
  • Della Penna S
  • Feinberg D
  • Glasser MF
  • Harel N
  • Heath AC
  • Larson-Prior L
  • Marcus D
  • Michalareas G
  • Moeller S
  • Oostenveld R
  • Petersen SE
  • Prior F
  • Schlaggar BL
  • Smith SM
  • Snyder AZ
  • Xu J
  • Yacoub E
  • WU-Minn HCP Consortium



Publication Data

October 1, 2012

Associated Grants

  • Agency: NIMH NIH HHS, Id: 1U54MH091657
  • Agency: Medical Research Council, Id: G0700399
  • Agency: NIAAA NIH HHS, Id: K05 AA017688
  • Agency: NIAAA NIH HHS, Id: R01 AA017915
  • Agency: NIMH NIH HHS, Id: U54 MH091657
  • Agency: NIMH NIH HHS, Id: U54 MH091657-01

Mesh Terms

  • Brain
  • Brain Mapping
  • Connectome
  • Humans