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Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

Methylation of histones is central to chromatin regulation, and thus previously unknown mechanisms regulating genome function can be revealed through the discovery of new histone methyl marks. Here we identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast. Set5's enzymatic activity functions together with the global chromatin-modifying complexes COMPASS and NuA4 to regulate cell growth and stress responses.

Pubmed ID: 22343720


  • Green EM
  • Mas G
  • Young NL
  • Garcia BA
  • Gozani O


Nature structural & molecular biology

Publication Data

March 5, 2012

Associated Grants

  • Agency: NIH HHS, Id: DP2 OD007447
  • Agency: NIH HHS, Id: DP2 OD007447-01
  • Agency: NIH HHS, Id: DP2OD007447
  • Agency: NIGMS NIH HHS, Id: R01 GM079641
  • Agency: NIGMS NIH HHS, Id: R01 GM079641
  • Agency: NCI NIH HHS, Id: T32 CA009302

Mesh Terms

  • Calibration
  • Chromatin
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Lysine
  • Methylation
  • Saccharomyces cerevisiae
  • Stress, Physiological