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Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Visual cortical surface area varies two- to threefold between human individuals, is highly heritable, and has been correlated with visual acuity and visual perception. However, it is still largely unknown what specific genetic and environmental factors contribute to normal variation in the area of visual cortex. To identify SNPs associated with the proportional surface area of visual cortex, we performed a genome-wide association study followed by replication in two independent cohorts. We identified one SNP (rs6116869) that replicated in both cohorts and had genome-wide significant association (P(combined) = 3.2 × 10(-8)). Furthermore, a metaanalysis of imputed SNPs in this genomic region identified a more significantly associated SNP (rs238295; P = 6.5 × 10(-9)) that was in strong linkage disequilibrium with rs6116869. These SNPs are located within 4 kb of the 5' UTR of GPCPD1, glycerophosphocholine phosphodiesterase GDE1 homolog (Saccharomyces cerevisiae), which in humans, is more highly expressed in occipital cortex compared with the remainder of cortex than 99.9% of genes genome-wide. Based on these findings, we conclude that this common genetic variation contributes to the proportional area of human visual cortex. We suggest that identifying genes that contribute to normal cortical architecture provides a first step to understanding genetic mechanisms that underlie visual perception.

Pubmed ID: 22343285

Authors

  • Bakken TE
  • Roddey JC
  • Djurovic S
  • Akshoomoff N
  • Amaral DG
  • Bloss CS
  • Casey BJ
  • Chang L
  • Ernst TM
  • Gruen JR
  • Jernigan TL
  • Kaufmann WE
  • Kenet T
  • Kennedy DN
  • Kuperman JM
  • Murray SS
  • Sowell ER
  • Rimol LM
  • Mattingsdal M
  • Melle I
  • Agartz I
  • Andreassen OA
  • Schork NJ
  • Dale AM
  • Alzheimer's Disease Neuroimaging Initiative
  • Pediatric Imaging, Neurocognition, and Genetics Study
  • Weiner M
  • Aisen P
  • Petersen R
  • Jack CR
  • Jagust W
  • Trojanowki JQ
  • Toga AW
  • Beckett L
  • Green RC
  • Saykin AJ
  • Morris J
  • Liu E
  • Montine T
  • Gamst A
  • Thomas RG
  • Donohue M
  • Walter S
  • Gessert D
  • Sather T
  • Harvey D
  • Kornak J
  • Dale A
  • Bernstein M
  • Felmlee J
  • Fox N
  • Thompson P
  • Schuff N
  • Alexander G
  • DeCarli C
  • Bandy D
  • Koeppe RA
  • Foster N
  • Reiman EM
  • Chen K
  • Mathis C
  • Cairns NJ
  • Taylor-Reinwald L
  • Trojanowki JQ
  • Shaw L
  • Lee VM
  • Korecka M
  • Crawford K
  • Neu S
  • Foroud TM
  • Potkin S
  • Shen L
  • Kachaturian Z
  • Frank R
  • Snyder PJ
  • Molchan S
  • Kaye J
  • Quinn J
  • Lind B
  • Dolen S
  • Schneider LS
  • Pawluczyk S
  • Spann BM
  • Brewer J
  • Vanderswag H
  • Heidebrink JL
  • Lord JL
  • Johnson K
  • Doody RS
  • Villanueva-Meyer J
  • Chowdhury M
  • Stern Y
  • Honig LS
  • Bell KL
  • Morris JC
  • Ances B
  • Carroll M
  • Leon S
  • Mintun MA
  • Schneider S
  • Marson D
  • Griffith R
  • Clark D
  • Grossman H
  • Mitsis E
  • Romirowsky A
  • deToledo-Morrell L
  • Shah RC
  • Duara R
  • Varon D
  • Roberts P
  • Albert M
  • Onyike C
  • Kielb S
  • Rusinek H
  • de Leon MJ
  • Glodzik L
  • De Santi S
  • Doraiswamy PM
  • Petrella JR
  • Coleman RE
  • Arnold SE
  • Karlawish JH
  • Wolk D
  • Smith CD
  • Jicha G
  • Hardy P
  • Lopez OL
  • Oakley M
  • Simpson DM
  • Porsteinsson AP
  • Goldstein BS
  • Martin K
  • Makino KM
  • Ismail MS
  • Brand C
  • Mulnard RA
  • Thai G
  • Mc-Adams-Ortiz C
  • Womack K
  • Mathews D
  • Quiceno M
  • Diaz-Arrastia R
  • King R
  • Weiner M
  • Martin-Cook K
  • DeVous M
  • Levey AI
  • Lah JJ
  • Cellar JS
  • Burns JM
  • Anderson HS
  • Swerdlow RH
  • Apostolova L
  • Lu PH
  • Bartzokis G
  • Silverman DH
  • Graff-Radford NR
  • Parfitt F
  • Johnson H
  • Farlow MR
  • Hake AM
  • Matthews BR
  • Herring S
  • van Dyck CH
  • Carson RE
  • MacAvoy MG
  • Chertkow H
  • Bergman H
  • Hosein C
  • Black S
  • Stefanovic B
  • Caldwell C
  • Ging-Yuek
  • Hsiung R
  • Feldman H
  • Mudge B
  • Assaly M
  • Kertesz A
  • Rogers J
  • Trost D
  • Bernick C
  • Munic D
  • Kerwin D
  • Mesulam MM
  • Lipowski K
  • Wu CK
  • Johnson N
  • Sadowsky C
  • Martinez W
  • Villena T
  • Turner RS
  • Johnson K
  • Reynolds B
  • Sperling RA
  • Johnson KA
  • Marshall G
  • Frey M
  • Yesavage J
  • Taylor JL
  • Lane B
  • Rosen A
  • Tinklenberg J
  • Sabbagh M
  • Belden C
  • Jacobson S
  • Kowall N
  • Killiany R
  • Budson AE
  • Norbash A
  • Johnson PL
  • Obisesan TO
  • Wolday S
  • Bwayo SK
  • Lerner A
  • Hudson L
  • Ogrocki P
  • Fletcher E
  • Carmichael O
  • Olichney J
  • Kittur S
  • Borrie M
  • Lee TY
  • Bartha R
  • Johnson S
  • Asthana S
  • Carlsson CM
  • Potkin SG
  • Preda A
  • Nguyen D
  • Tariot P
  • Fleisher A
  • Reeder S
  • Bates V
  • Capote H
  • Rainka M
  • Scharre DW
  • Kataki M
  • Zimmerman EA
  • Celmins D
  • Brown AD
  • Pearlson GD
  • Blank K
  • Anderson K
  • Santulli RB
  • Schwartz ES
  • Sink KM
  • Williamson JD
  • Garg P
  • Watkins F
  • Ott BR
  • Querfurth H
  • Tremont G
  • Salloway S
  • Malloy P
  • Correia S
  • Rosen HJ
  • Miller BL
  • Mintzer J
  • Longmire CF
  • Spicer K
  • Finger E
  • Rachinsky I
  • Drost D
  • Jernigan T
  • McCabe C
  • Grant E
  • Ernst T
  • Kuperman J
  • Chung Y
  • Murray S
  • Bloss C
  • Darst B
  • Pritchett L
  • Saito A
  • Amaral D
  • DiNino M
  • Eyngorina B
  • Sowell E
  • Houston S
  • Soderberg L
  • Kaufmann W
  • van Zijl P
  • Rizzo-Busack H
  • Javid M
  • Mehta N
  • Ruberry E
  • Powers A
  • Rosen B
  • Gebhard N
  • Manigan H
  • Frazier J
  • Kennedy D
  • Yakutis L
  • Hill M
  • Gruen J
  • Bosson-Heenan J
  • Carlson H

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Data

March 6, 2012

Associated Grants

  • Agency: NCRR NIH HHS, Id: 5UL1RR025774
  • Agency: NIMH NIH HHS, Id: N01MH22005
  • Agency: NIA NIH HHS, Id: P30 AG008051
  • Agency: NICHD NIH HHS, Id: P30 HD004147
  • Agency: NIBIB NIH HHS, Id: P41 EB015909
  • Agency: NIMH NIH HHS, Id: P50MH081755
  • Agency: NINDS NIH HHS, Id: P50NS22343
  • Agency: NIA NIH HHS, Id: R01 AG012101
  • Agency: NIA NIH HHS, Id: R01 AG013616
  • Agency: NIA NIH HHS, Id: R01 AG022374
  • Agency: NIMH NIH HHS, Id: R01 MH083320
  • Agency: NIA NIH HHS, Id: R01AG030474
  • Agency: NIA NIH HHS, Id: R01AG031224
  • Agency: NIA NIH HHS, Id: R01AG035020
  • Agency: NIA NIH HHS, Id: R01AG22381
  • Agency: NIDA NIH HHS, Id: R01DA030976
  • Agency: NHLBI NIH HHS, Id: R01HL089655
  • Agency: NIMH NIH HHS, Id: R01MH078151-01A1
  • Agency: NIMH NIH HHS, Id: R01MH080134
  • Agency: NIDA NIH HHS, Id: RC2 DA029475
  • Agency: NIDA NIH HHS, Id: RC2DA029475
  • Agency: NIA NIH HHS, Id: U01 AG024904
  • Agency: NIDA NIH HHS, Id: U01DA024417
  • Agency: NIA NIH HHS, Id: U19AG023122-01
  • Agency: NCI NIH HHS, Id: U54CA143906
  • Agency: NINDS NIH HHS, Id: U54NS056883
  • Agency: NCRR NIH HHS, Id: UL1 RR033173

Mesh Terms

  • Adolescent
  • Adult
  • Aged
  • Brain
  • Brain Mapping
  • Cohort Studies
  • Diagnostic Imaging
  • Female
  • Genetic Variation
  • Genome-Wide Association Study
  • Genomics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Phosphoric Diester Hydrolases
  • Polymorphism, Single Nucleotide
  • Saccharomyces cerevisiae
  • Visual Cortex