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A mouse model of the most aggressive subgroup of human medulloblastoma.

Cancer cell | Feb 14, 2012

http://www.ncbi.nlm.nih.gov/pubmed/22340591

Medulloblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.

Pubmed ID: 22340591 RIS Download

Mesh terms: Animals | Cell Proliferation | Cell Transformation, Neoplastic | Cerebellar Neoplasms | Disease Models, Animal | Gene Expression Regulation, Neoplastic | Hedgehog Proteins | Humans | Medulloblastoma | Mice | Salivary alpha-Amylases | Transcriptome | Tumor Suppressor Protein p53 | Veratrum Alkaloids

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Associated grants

  • Agency: NCI NIH HHS, Id: CA-096832
  • Agency: NCI NIH HHS, Id: CA-21765
  • Agency: NCI NIH HHS, Id: P01 CA096832
  • Agency: NCI NIH HHS, Id: P01 CA096832-08
  • Agency: NCI NIH HHS, Id: R01 CA129541

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