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IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme.

BMC immunology | 2012

SWI/SNF chromatin remodeling enzymes play a critical role in the development of T helper lymphocytes, including Th2 cells, and directly program chromatin structure at Th2 cytokine genes. Different versions of SWI/SNF complexes, including BAF and PBAF, have been described based on unique subunit composition. However, the relative role of BAF and PBAF in Th cell function and cytokine expression has not been reported.

Pubmed ID: 22336179 RIS Download

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL109054
  • Agency: Intramural NIH HHS, United States

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