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SynaptomeDB: an ontology-based knowledgebase for synaptic genes.

MOTIVATION: The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking. RESULTS: We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.

Pubmed ID: 22285564

Authors

  • Pirooznia M
  • Wang T
  • Avramopoulos D
  • Valle D
  • Thomas G
  • Huganir RL
  • Goes FS
  • Potash JB
  • Zandi PP

Journal

Bioinformatics (Oxford, England)

Publication Data

March 15, 2012

Associated Grants

  • Agency: NIMH NIH HHS, Id: K01 MH093809
  • Agency: NIMH NIH HHS, Id: K01 MH093809-01
  • Agency: NIMH NIH HHS, Id: K01 MH093809-02
  • Agency: NIMH NIH HHS, Id: K01-MH093809
  • Agency: NIMH NIH HHS, Id: R01 MH087979
  • Agency: NIMH NIH HHS, Id: R01-MH083738
  • Agency: NIMH NIH HHS, Id: R01-MH087979

Mesh Terms

  • Databases, Genetic
  • Genomics
  • Humans
  • Internet
  • Knowledge Bases
  • Proteins
  • Synapses